Brain-derived neurotrophic factor or BDNF plays a significant role in neuronal survival and development, serves as a neurotransmitter modulator, and participates in neuronal plasticity, which is vital for memory and learning. It's broadly expressed in the CNS, gut and other cells.
BDNF binds into a high-affinity receptor TrkB and triggers signal transduction cascades, essential for CREB and CBP generation, which encode proteins involved in β cell survival. You can know more about the human BDNF ELISA kit via Boster Bio.
BDNF and insulin-like growth factor-1 have comparable downstream signaling mechanisms comprising both p-CAMK and MAPK that increase the manifestation of pro-survival genes. Brain-derived neurotrophic factor modulates energy and glucose metabolism and prevents fatigue of β cells.
Reduced levels of BDNF are related to neurodegenerative disorders with neuronal loss, for example Parkinson's disease, Alzheimer's disease, multiple sclerosis and Huntington's disease. Therefore, BDNF might be helpful in the prevention and control of many diseases like diabetes mellitus. The BDNF gene provides instructions for making a protein within the brain and spinal cord known as brain-derived neurotrophic element.
The BDNF protein helps modulate synaptic plasticity, which can be essential for memory and learning. The BDNF protein is located in areas of the brain which control drinking, eating, and body fat. The Individual BDNF ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human BDNF in serum, plasma, cell culture supernatants and pee.
The brain derived neurotrophic factor (BDNF) gene is mapped to human chromosome. BDNF is a part of the neurotrophin family of growth factors. The gene encodes a precursor protein, proBDNF. Mature BDNF (mBDNF) is synthesized by post-translational cleavage of proBDNF. The two proBDNF and mBDNF play critical roles in cellular signaling.